Marios Dimopoulos Clinical Nutritionist, Author, Fellow of the American Council of the Applied Clinical Nutrition

Κυριακή, 9 Φεβρουαρίου 2014

Tocotrienols and citrus flavonoids lower cholesterol by 20-30 percent

A study shows the power of natural substances to help promote healthy levels of cholesterol. A combination of tocotrienols and citrus-derived polymethoxylated flavones were tested on men and women with high cholesterol (total greater than 230).  The two open-label studies and one double-blind study varied in length from four to12 weeks.
Researchers found a significant reduction in total cholesterol (20 percent - 30 percent), LDL (19 percent - 27 percent), apolipoprotein B (21 percent), and triglycerides (24 percent - 34 percent).
The ability of concentrated natural products to help support a healthy cholesterol level is certainly good news, as these substances have no adverse side effects.

Roza JM, Xian-Liu Z, Guthrie N. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Altern Ther Health Med.   2007 November  13(6):44-8.
SourceOne Global Partners, Chicago, Illinois, USA.

Study Abstract:

CONTEXT: Preliminary studies have suggested that both citrus flavonoids and palm tocotrienols reduce cholesterol levels in laboratory animals. OBJECTIVE: To examine the effect of these nutrients in combination on blood levels of cholesterol and related cardiovascular disease risk factors. DESIGN: Two open-label studies and 1 double-blind study are reported.
SETTING: Outpatient clinical research setting.
PATIENTS: Three groups (n=10, n=10, n=120) of hypercholesterolemic men and women (cholesterol levels >230 mg/dL) between the ages of 19 and 65 years were recruited. INTERVENTION: Subjects were randomized to consume either 270 mg citrus flavonoids plus 30 mg tocotrienols (S) or placebo (P) daily for a period of 4 weeks (group 1 [G1] and group 2 [G2]) or 12 weeks (group 3 [G3]). MAIN
OUTCOME MEASURES: Measurements of fasting levels of blood cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were made at baseline and 4 weeks (all groups) and at 8 weeks and 12 weeks (G3).
RESULTS: Daily treatment with S significantly improved cardiovascular parameters compared to P in all groups. Significant reductions were shown in total cholesterol (20%-30%), LDL (19%-27%), apolipoprotein B (21%), and triglycerides (24%-34%). HDL levels remained unchanged in G1 and G2 but increased 4% (nonsignificant) in G3 and was accompanied by a significant increase in apolipoprotein A1 (5%).

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