Daily multivitamin supplement may decrease cataract risk in men

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Long-term daily multivitamin supplement use may lower cataract risk by around 9%, according to a new trail of 15.000 men.
The findings published in the journal Ophthalmology.
Read:

 http://www.nutraingredients.com/Research/Daily-multivitamin-supplement-may-decrease-cataract-risk-in-men-RCT-data

Effects of Multivitamin Supplement on Cataract and Age-Related Macular Degeneration in a Randomized Trial of Male Physicians

• William G. Christen, ScD
,
• Robert J. Glynn, ScD
,
• JoAnn E. Manson, MD, DrPH
,
• Jean MacFadyen, BA
,
• Vadim Bubes, PhD
,
• Miriam Schvartz, MD
,
• Julie E. Buring, ScD
,
• Howard D. Sesso, ScD, MPH
,
• J. Michael Gaziano, MD, MPH

Purpose

To test whether long-term multivitamin supplementation affects the incidence of cataract or age-related macular degeneration (AMD) in a large cohort of men.

Design

Randomized, double-blind, placebo-controlled trial.

Participants

A total of 14 641 US male physicians aged ≥50 years.

Intervention

Daily multivitamin or placebo.

Main Outcome Measures

Incident cataract and visually significant AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-reports confirmed by medical record review.

Results

During an average of 11.2 years of treatment and follow-up, a total of 1817 cases of cataract and 281 cases of visually significant AMD were confirmed. There were 872 cataracts in the multivitamin group and 945 cataracts in the placebo group (hazard ratio [HR], 0.91; 95% confidence interval [CI], 0.83–0.99; P = 0.04). For visually significant AMD, there were 152 cases in the multivitamin group and 129 cases in the placebo group (HR, 1.19; 95% CI, 0.94–1.50; P = 0.15).

Conclusions

These randomized trial data from a large cohort of middle-aged and older US male physicians indicate that long-term daily multivitamin use modestly and significantly decreased the risk of cataract but had no significant effect on visually significant AMD.

http://www.aaojournal.org/article/S0161-6420%2813%2900883-X/abstract