Structural properties of EGCG-induced, nontoxic Alzheimer’s disease Aβ oligomers

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
Structural properties of EGCG-induced, nontoxic Alzheimer’s disease Aβ oligomers
According to the study by the Deutsches Forschungszentrum für Gesundheit und Umwelt, EGCG interferes with the aromatic hydrophobic core of Aβ. The C-terminal part of the Aβ peptide (residues 22-39) adopts a β-sheet conformation, whereas the N-terminus (residues 1-20) is unstructured. The characteristic salt bridge involving residues D23 and K28 is present in the structure of these oligomeric Aβ aggregates as well. The structural analysis of small-molecule-induced amyloid aggregates will open new perspectives for Alzheimer’s disease drug(24).
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Sources
24. http://www.ncbi.nlm.nih.gov/pubmed/22300765